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Jama neurology
Jama neurology. β-Amyloid load, phosphorylated tau tangle, and global AD pathology were square root–transformed. This cross-sectional cohort study evaluates plasma glial fibrillary acidic protein levels throughout the entire Alzheimer disease continuum, from preclinical Alzheimer disease to Alzheimer disease dementia, compared with cerebrospinal fluid glial fibrillary acidic protein. This randomized clinical trial evaluates the efficacy and safety of XEN1101, a potassium channel opener, in the treatment of adults with intractable focal-onset seizures. Jul 2, 2020 · In this Viewpoint, JAMA Neurology editors review the journal’s more important articles advancing scientific understanding of COVID-19 in the first 6 months of the pandemic, including surveys of neurologic manifestations of the infection and identification of potential direct viral involvement in the Key Points. brightcove-video {margin: 2em 0;} . 3% greater than nonveterans, and suicide was the second leading cause of death for veterans younger than 45 years. a Indicates a statistically significant interaction was detected between high school education (P = . Findings In this randomized clinical trial of 263 patients with LGS, use of 0. Question Is there an association between dementia diagnosis and a higher risk of suicide?. 1 The prevalence of M pruriens supplement use in the US is unknown, but a recent survey of 205 patients with Parkinson 5 Research Unit for Neurology, Odense University Hospital, University of Southern Denmark, Odense, Denmark Dementia is a set of neurocognitive conditions marked by a gradual deterioration of cognitive capacity that interferes with daily life, with Alzheimer disease being the most common. This single-center open-label nonrandomized, noncontrolled trial assesses the safety, tolerability, cerebrospinal fluid penetration, and biochemical changes associated with ambroxol therapy for the treatment of patients with Parkinson disease with and without mutations in the glucocerebrosidase With our impact factor rising again to 18. These specific aims are 6 days ago · Stay up to date, maintain your CME with the latest research, author interviews, apps, and learning courses from JAMA and the Specialty Journals. Question How common are persistent, injury-related functional limitations following mild traumatic brain injury vs orthopedic trauma?. Patients were screened by acute care clinicians from the affiliated centers, mainly the departments of neurology and neurosurgery. Find local businesses, view maps and get driving directions in Google Maps. Question Can a blood test based on the ratio of plasma phosphorylated tau 217 (p-tau217) relative to non–p-tau217 (expressed as percentage of p-tau217) combined with the amyloid-β 42 and amyloid-β 40 plasma ratio (the amyloid probability score 2 [APS2]) accurately identify Alzheimer disease in primary care and secondary care when prospectively applying predefined biomarker Read the December 1, 2021 issue. Volume 78, Number 12. Question What was the prevalence of dementia and mild cognitive impairment (MCI) in the US in 2016?. 1 Between 2000 and 2020, over 460 000 US service members were diagnosed with traumatic brain injuries (TBIs). 18) [1]. It was established in 1960 as Archives of Neurology and obtained its current name in 2013. Read the March 1, 2021 issue. Findings In this nationally representative case-control study including 594 674 persons in England from 2001 through 2019, dementia was found to be associated with increased risk of suicide in specific patient subgroups: those diagnosed before age 65 years (particularly in the 3-month The y-axis represents the adjusted mean changes values from baseline, from mixed models with repeated measures (MMRM) models. Question Is posttraumatic epilepsy (PTE) associated with long-term dementia risk?. Findings In this cohort study of 23 deceased patients with COVID-19 and 14 matched controls, more severe axon pathology, axon losses, and microvascular pathology were noted in olfactory tissue from patients with COVID-19 than that from the control individuals. This secondary analysis of a randomized clinical trial determines whether evoked compound action potentials–controlled, closed-loop spinal cord stimulator is associated with better outcomes compared with fixed-output, open-loop spinal cord stimulator at 24 months following implant. Question Are benzodiazepines or antihistamines effective in the treatment of acute vertigo?. 3,4 We Key Points. Dec 4, 2020 · Autosomal dominant early onset Alzheimer's disease in the Mexican state of Jalisco: High frequency of the mutation PSEN1 c. 3, the quality of manuscripts published in JAMA Neurology has never been better. Search Strategy PubMed/EMBASE. Findings In this cohort study of 1154 patients with mild traumatic brain injury and 299 patients with orthopedic trauma serving as controls, 53% of participants with mild traumatic brain injury reported impairment 12 months postinjury vs 38% of Key Points. One example is Mucuna pruriens, a bean containing levodopa, which has been investigated as a potential treatment for Parkinson disease. We adjusted for variables regarded as common causes of depression and dementia based on current knowledge that were measured at baseline: education, income, cardiovascular disease, chronic obstructive pulmonary disease, diabetes, anxiety disorders, stress disorders, substance use APTT indicates abnormal activated partial thromboplastin time; ARAMIS, Antiplatelet vs R-tPA for Acute Mild Ischemic Stroke; MRI, magnetic resonance imaging; NIHSS, National Institutes of Health Stroke Scale; SBP, systolic blood pressure. In 2020, the suicide rate among US veterans was 31. 01) and minor to mild stroke (NIHSS ≤ 10). A follow-up of the Restart or Stop Antithrombotics Randomized Trial, this study further examines the long-term effects of antiplatelet therapy after stroke caused by intracerebral hemorrhage. vjs-big-play-button. Models A, B, and C included an interaction term between lifestyle score and brain pathology (eg, β-amyloid load) and were adjusted for age at death, sex, education, APOE e4, and time intervals from the last assessment to death (in years) and from death to autopsy (in hours). 5 times higher risk of dementia compared with individuals without a history of head injury or seizure/epilepsy. Volume 79, Number 2. Diagnostic Codes for Neurological Exclusions. Botanical supplements may contain pharmaceutically active drugs that affect the presentation, natural history, and management of disease. Findings In this individual pooled study of longitudinal data on nearly 50 000 participants from 4 population-based cohort studies, intracerebral hemorrhage was associated with an approximately 2-fold increased risk of ischemic stroke and myocardial infarction This diagnostic study explores whether positron emission tomography with [18F]flortaucipir can detect tau pathology and Alzheimer disease neuropathologic changes in terminally ill adults with or without dementia. Findings This nationally representative cross-sectional study found that approximately one-third of 3496 individuals 65 years and older had dementia or MCI. 35-2. This multicenter cohort study uses real-world clinical data to compare the long-term safety and effectiveness of intravenous edaravone plus riluzole therapy vs propensity score–matched controls receiving riluzole therapy alone among patients with amyotrophic lateral sclerosis. Question Is there an association between intracerebral hemorrhage and an increased risk of arterial ischemic events?. In the setting of the coronavirus disease 2019 (COVID-19) pandemic, the journal had to rapidly evolve to handle a record number of manuscripts and respond to the needs of our readers to be informed of the most timely and important neurological information about the virus. Dietary aluminum ingestion is theorized to be neurotoxic and play a causative role in the onset and progression of dementia. This randomized clinical trial examines the efficacy and adverse effects of donanemab, a monoclonal antibody designed to clear brain amyloid plaque, among patients with early symptomatic Alzheimer disease. It is part of the JAMA Network family of journals and has a high impact factor and fast editorial process. Mar 16, 2018 · Functional neurological disorders (FND) are among the most common causes of neurological disability. Each week, our team of associate editors meets as a group to discuss every manuscript that has been sent for peer review and is being considered for revision. Browse the latest online issues, editor's choice articles, and clinical reviews and education topics. 7 per 100 000, 57. Forest Plot of Tinnitus Prevalence in Children and Adolescents, by Different Definition Classes of Any Tinnitus Mission Statement: The mission of JAMA Neurology is to publish scientific information primarily important for those physicians caring for people with neurologic disorders but also for those interested in the structure and function of the normal and diseased nervous system. Sep 9, 2024 · JAMA Neurology is a peer-reviewed journal that publishes original research, reviews, editorials, and opinions on neurological disorders and brain science. Jan 30, 2019 · Key Points. eFigure 1. 71, 95% confidence interval (CI), 1. 1292C>A and phenotypic profile of patients - Dumois‐Petersen - 2020 - American Journal of Medical Genetics Part C: Seminars in Medical Genetics - Wiley Online Library. The last 12 months have been unprecedented here at JAMA Neurology. Findings This meta-analysis of 28 studies found a high prevalence of suicidal ideation and behavior in patients with PD. 1 This process may adversely affect household wealth, a key social determinant of health, due to negative outcomes of financial decision capacity 2 and need for expensive medical and long-term care services. For Authors | JAMA Network . This paper suggests that the majority of the patients (78/116) with cerebral venous sinus thrombosis (CVST) presented incidences of thrombosis with thrombocytopenia syndrome (TTS) after SARS-CoV-2 vaccination of two vaccines under study, and patients presented CVST-TTS after the vaccination had high rates of coma and intracerebral hemorrhage and a high mortality rate. Read the January 1, 2022 issue. 7-mg/kg/d fenfluramine resulted in a greater reduction in drop seizures than with placebo, more patients achieving a 50% or greater reduction in drop seizure frequency, and greater reduction in generalized tonic Key Points. brightcove-video . Findings In this systematic review and meta-analysis of 17 trials involving 1586 participants, 7 studies comprising 802 total patients evaluated the primary outcome of change in 100-point vertigo visual analog scale scores at approximately 2 hours after treatment with an antihistamine or Jun 30, 2023 · Key Points. 2 Veterans serving after 9/11 have higher suicide rates compared to the US population, which is Read the June 1, 2022 issue. Supplement 1. JAMA Neurology is a weekly online and monthly print journal that publishes original research and observations on the nervous system. Availability and Details of Standard Operating Procedures Regarding Intravenous Thrombolysis in Patients With Recent Ingestion of Direct Oral Anticoagulants Key Points. Mission Statement: The mission of JAMA Neurology is to publish and disseminate scientific information primarily important for physicians caring for people with neurologic disorders and for those interested in the structure and function of the normal and diseased human nervous system. Findings In this randomized clinical trial with 345 patients, brexpiprazole, 2 mg/d or 3 mg/d, demonstrated a statistically significant reduction in agitation (Cohen-Mansfield Agitation Inventory score) vs placebo over 12 weeks. The covariates of the models included baseline age, respective baseline cognitive/functional test scores, visit number (used as a categorical variable), tau status-by-visit interaction, and baseline ANART for Study 1, or education and treatment arms for Study 2. Question Is adjunctive fenfluramine effective in patients with Lennox-Gastaut syndrome (LGS)?. We used Cox proportional hazards regression analysis to estimate the association between depression and dementia. Question What is the prevalence and risk of suicidal ideation and behavior in patients with Parkinson disease (PD)?. eTable 2. Background: Neuromyelitis Optica Spectrum Disorders (NMOSD) are a group of inflammatory diseases of the Central Nervous System (CNS) that primarily affect the optic nerve and spinal cord, usually with a severe and relapsing course. . Read the February 1, 2022 issue. As we turn the page on 2023, we here at JAMA Neurology want to once again thank all of our readers, authors, and peer reviewers (who are listed elsewhere)1 for their continued support and contributions. Question What are the neuropathologic changes of COVID-19 in the olfactory region?. Read the November 1, 2021 issue. Topics include Parkinson disease, Alzheimer disease, atrial fibrillation, multiple sclerosis, and more. Prevalence and Age- and Sex-Adjusted Odds Ratios of PD for Comorbidities and Risk Factors According to Time of Presentation This cohort study analyzes data from representative private, military, and public health insurance data sets to calculate the national prevalence of multiple sclerosis among Hispanic, non-Hispanic Black, and non-Hispanic White individuals in the United States. 4%), with nearly all having mild CTE (stages I and II). This randomized clinical trial assesses the long-term effects on patient-rated quality of life of adjuvant treatment with dopamine reuptake inhibitors compared with dopamine agonists among patients with motor complications of Parkinson disease that are inadequately controlled by levodopa therapy. eTable 3. This phase 1b randomized clinical trial assesses the safety and tolerability of the antiamyloid ACI-24 vaccine and investigates the vaccine’s ability to induce immunogenicity among adults with Down syndrome at risk of developing a genetic form of Alzheimer disease. The spectrum of ICI-induced encephalitis (ICI-iE) ranges from disease that resolves fully to lethal forms. Key Points. This randomized clinical trial investigates the safety and efficacy of ApTOLL as a neuroprotectant drug for patients with ischemic stroke when given in combination with endovascular treatment. A recent meta-analysis showed that individuals chronically exposed to aluminum were 71% more likely to develop AD (OR: 1. Jul 28, 2024 · Key Points. HRs and 95% CIs were calculated from cause-specific, multivariable Cox proportional hazards regression models. Volume 79, Number 6. a Other reasons for not meeting inclusion and exclusion criteria include inability to comply with study requirements; presence of diabetes that, in the judgment of the investigator, cannot be controlled or adequately managed; inability to understand the purpose and risks of the study and Importance The Neurosarcoidosis Consortium Consensus Group, an expert panel of physicians experienced in the management of patients with sarcoidosis and neurosarcoidosis, engaged in an iterative process to define neurosarcoidosis and develop a practical diagnostic approach to patients with suspected neurosarcoidosis. Importance Encephalitis is a severe immune-related adverse event secondary to treatment with immune checkpoint inhibitors (ICIs). vjs-big-play-button {-webkit-transform: none;transform: none;} For Authors Information, Instructions for Authors, and additional resources for authors interested in submitting manuscripts to the JAMA Network journals—JAMA, JAMA Network Open, and the 11 JAMA specialty journals—are available This randomized clinical trial showed that use of ultrahigh-dose methylcobalamin in Japanese patients in the early stages of amyotrophic lateral sclerosis with moderate progression can slow functional decline and had a good safety profile. Numbers of screened patients were not recorded in all affiliated hospitals (eTable 2 in Supplement 2). Explore the latest in dementia and cognitive impairment, including advances in diagnosis, management, and prevention of the disorders. To determine the frequency of and challenges to documentation of advance care planning (ACP) in people with dementia, we conducted a chart review of 746 deceased patients seen at a tertiary memory care center between 2012 and 2017. This case series assesses the safety and effectiveness of staged bilateral magnetic resonance imaging (MRI)–guided focused ultrasound subthalamotomy to treat motor features of Parkinson disease. Diagnostic Codes for Exposures. Feb 3, 2021 · Background and Objectives. eTable 1. Over the 7 years that our team has been fortunate enough to steward this amazing publication, our Key Points. Corticolimbic index (CLix) quantitatively defines corticolimbic vulnerability as a continuous measure (range, 0-40) calculated from the means and proportions of thioflavin-S–positive neurofibrillary tangle counts from hippocampus (CA1 and subiculum) and association cortices (superior temporal, inferior parietal, and middle frontal). The specific Importance Neuropsychiatric syndromes (NPSs) are common in neurodegenerative disorders (NDDs); compromise the quality of life of patients and their care partners; and are associated with faster disease progression, earlier need for nursing home care, and poorer quality of life. JAMA Neurology is a monthly peer-reviewed medical journal published by the American Medical Association. Flow Chart of the Present Systematic Review. 1 These conditions have had a long and difficult history of mind-body dualism and have now reached better-defined pathophysiological and neurobiological bases that challenge old assumptions of psychological abnormalities as their sole cause (in other words, their status as a psychogenic illness). Browse the latest research and commentary on neurological disorders and diseases in the August 2024 issue of JAMA Neurology. Supplement. This case report describes a woman in her 20s who was diagnosed with systemic lupus erythematosus-Sjögren overlap syndrome and had chronic inflammatory demyelinating polyneuropathy. Volume 78, Number 11. Volume 79, Number 1. ApoE indicates apolipoprotein E; MRI, magnetic resonance imaging; PET, positron emission tomography. Findings In this case series of 152 contact sport athletes younger than 30 years at the time of death, chronic traumatic encephalopathy (CTE) was found in 63 (41. Volume 78, Number 3. This narrative review evaluates the literature pertaining to neural antibody frequency in epilepsy populations, highlights key findings across studies that characterize populations in which antibody positivity is more likely, and identifies gaps and limitations in the literature to clarify what directions should be considered for future Supplement. eFigure 2. Question Is brexpiprazole an efficacious, safe, and well-tolerated treatment for agitation in patients with Alzheimer dementia?. Mixed linear regression models with random intercepts and slopes were adjusted for age, sex, race and ethnicity, education, income, physical activity, body mass index, hypertension, diabetes, cardiovascular disease, depressive symptoms, alcohol consumption, smoking, total calories, and healthy eating score. Findings In this prospective cohort study of 12 558 adults enrolled in the Atherosclerosis Risk in Communities study who were followed-up for up to 30 years, individuals with PTE had 4. A, Proportion with minimal disease manifestations at each study visit defined as Quantitative Myasthenia Gravis score ≤4 and a dose of prednisolone, ≤10 mg, without protocol-defined rescue treatment. Jun 14, 2022 · This cohort study examines data from 3 single-center observational cohorts to test the capabilities of a commercially available plasma phosphorylated tau 217 immunoassay to identify Alzheimer disease pathophysiology. This cohort study uses data from the Health and Retirement Study to assess for changes in racial disparities in Alzheimer dementia prevalence and incidence among non-Hispanic Black and White individuals in the US from 2000 to 2016. Question What are the neuropathologic and clinical findings in a convenience sample of young, deceased, symptomatic contact sport athletes?.
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